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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might end in an increase in methadone plasma concentrations, which could result in most likely deadly respiratory melancholy. In addition, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally